Found the following hamletworks.org entries referring to line 621+21

View Commentary Note for 621+20
621+20 {From that particuler fault: the dram of eale}1.4.36

View Commentary Note for 621+21
621+21 {Doth all the noble substance of a doubt}1.4.37

View Material Textual Note for 621+21
621+21 {Doth all the noble substance of a doubt}1.4.37

View Commentary Note for 621+22
621+22 {To his owne scandle.} 1.4.38