Found the following hamletworks.org entries referring to line 281

View Immaterial Textual Note for 271
271 But you must knowe your father lost a father,1.2.89

View Commentary Note for 280
280 For what we knowe must be, and is as common 1.2.98

View Commentary Note for 281
281 As any the most vulgar thing to sence, {C1} 

View Material Textual Note for 281
281 As any the most vulgar thing to sence, {C1}